Endocrine Abstracts

Introduction: Maternally-inherited diabetes with deafness (MIDD) is a rare form of monogenetic diabetes caused by a point mutation in mitochondrial DNA at a position 3243A>G. The syndrome is characterised by diabetes and sensoneural hearing impairment. Additional clinical features include short stature, cardiomyopathy, myopathy, renal disease, macular dystrophy, and gastrointestinal disease. The majority of patients usually require insulin therapy within 2 years and metfor...

Introduction: Topical wound oxygen therapy (TWO2) is therapeutic modality that delivers humidified pressurised O2 directly to the specific body part to achieve tissue penetration and increased O2 levels to the open ischaemia wound. O2 is vital in the synthesis of collagen, enhancement of fibroblasts, angiogenesis, leukocyte function, energy metabolism, and the inhibition of mycrobial growth. TWO2 therapy has showed effecti...

Aim: The aim of the study was to compare HbA1c levels in patients with type 1 diabetes before and 3 months after the transition from pediatric to adult endocrinology clinic.Methods: Retrospective analysis of the data from 88 young adults with type 1 diabetes was done. The consecutive patients were recruited in their last year of pediatric care and then transferred to the adult endocrinologist care. A group of 25 randomly chosen patients underwent structu...

Introduction: Brown tumour is a rare, benign, tumour-like lesion of bones.The presence of brown tumour is a rare complication of uncontrolled primary, secondary or tertiary hyperparathyroidism.Brown tumours can be solitary or multifocal and are most commonly located in ribs, clavicles, pelvic girdle, extremities and facial bones (maxilla, mandible, and hard palate).A diagnosis of brown tumour in hyperparathyroidism is established by evaluation of serum calcium, phosphorus and ...

Introduction: GLP-1 agonists and metformin are widely used antidiabetic drugs with excellent blood glucose-lowering effects, but patients very often develop side effects. The most common side effect of these two groups of drugs is gastrointestinal intolerance in the form of vomiting, diarrhoea, general weakness and dizziness.Case ReportA 58-year-old male patient was hospitalised for the second time in one month due to a recurrence of dizziness, vomiting, ataxia and epileptic s...

A 57-year-old female patient was presented to the neurologist in the ER because of her first grand mal-type seizure. Initial examination in the emergency department confirmed hyponatremia (Na 131 mmol/l) in laboratory findings, while CT scan of the brain and EEG were normal. During hospitalization, additional laboratory and imaging studies were performed. Neuroradiological examination was performed (CT scan of the brain, MRI of the brain and MRI of the pituitary gland), which ...

Addison’s disease (primary adrenal cortical failure) is the lack of glucocorticoids due to disease of the adrenal gland. At 1855, when Addison described it tuberculosis (TB) was the main etiology. May be we are coming to that time. TB is an infectious disease caused by Mycobacterium tuberculosis. The most commonly (third of the patients) affects the lungs, as well as the other organs. Symptoms of the disease are non specific and are deteriorating slowly, so the d...

Aim: To determine clinical predictors of parathyroid gland carcinoma recurrence.Methods: We evaluated outcome of eight patients with primary hyperparathyroidism due to parathyroid carcinoma who were followed at University Hospital Centre Zagreb in period from 2004 to 2014. The median follow-up was 6 (range 2–14.5) years. Six patients (three male, three female; median age 57.5 (42–71) years) experienced long-term remission after the surgery wher...

Female patient (56 y) with hyperthyroidism (start TSH 0.01 mIU/l; fT3 15.8 pmol/l; fT4 39.4 pmol/l) one month after initiation of thiamazole therapy (10 mg 3 × 1/1 week, then 2 × 1) came to the emergency room with symptoms of sweating, palpitations, nervousness, itching, fever (37.6 C), icterus. In medical history: oesophageal achalasia surgery 5 years ago, non-smoker. Therapy: thiamazole, bisoprolol, alprazolam. Initially in laboratory findi...

Distinguishing type 1 from type 2 diabetes mellitus (DM) depends on clinical presentation, titers of antibodies and requirement for insulin therapy. Need for insulin per se is not a major difference between those two types. We measured the presence of antibodies for glutamic acid decarboxylase (GAD), islet–cell antibodies (ICA), insulinoma–associated protein 2 (IA–2) and the level of C–peptide in a group of 10 patients whose diagnosis of type 2 DM was e...